Zeptide 5mg/0.5ml Pre-filled Syringe

✔️ Uses

Treat type 2 diabetes

✔️ Dosage & Administration

Initial Dose:

Start with 2.5 mg subcutaneously once weekly for 4 weeks.

Titration: Increase by 2.5 mg increments every 4 weeks as tolerated.

Maximum dose: 15 mg once weekly.

Administration Instructions:

• Inject under the skin (subcutaneously) in the abdomen, thigh, or upper arm.
• Rotate injection sites to avoid lipodystrophy.
• Administer on the same day each week, with or without meals.
• Inspect the solution for clarity; discard if discolored or contains particles.
• Use a new needle for each injection. Never share pens.

Missed Dose:

If a dose is missed, administer within 4 days. If more than 4 days have passed, skip and resume the regular schedule.

✔️ Adverse Effects of

Common:

• Nausea, vomiting, diarrhea
• Abdominal pain
• Injection site reactions
• Loss of appetite

Serious:

• Pancreatitis
• Thyroid tumors
• Acute kidney injury
• Gallbladder disease (e.g., cholelithiasis, cholecystitis)
• Hypoglycemia (especially with insulin/sulfonylureas)
• Diabetic retinopathy
• Severe allergic reactions (e.g., anaphylaxis, angioedema)
• Behavioral changes, suicidal thoughts

✔️ Drug Interactions

Avoid or Use with Caution:

Hormonal Contraceptives (e.g., Desogestrel, Drospirenone, Levonorgestrel)

Tirzepatide may reduce oral contraceptive efficacy.

Warfarin

May alter INR; monitor closely.

Other Antidiabetics:

Risk of hypoglycemia when used with sulfonylureas or insulin. Monitor glucose levels and adjust dose if needed.

Other Interactions

Alcohol: Increases risk of hypoglycemia.

Food: Can be administered with or without food.

Smoking: No specific interactions documented, but lifestyle factors may impact glycemic control.

✔️ Use in Special Populations

• Pediatric: Safety and efficacy not established.
• Geriatric: No age-related restrictions, but elderly patients may be more sensitive.
• Pregnancy: Avoid use. Discontinue at least 2 months before planned conception (especially with Mounjaro®). Zepbound® may pose fetal risks.
• Breastfeeding: Data is insufficient; use only if benefits outweigh risks.

✔️ Contraindications

• Personal or family history of medullary thyroid carcinoma (MTC)
• Patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
• Severe gastroparesis
• Type 1 diabetes mellitus

✔️ Precautions

• Monitor thyroid health. Report neck masses, hoarseness, or dysphagia.
• Use cautiously in patients with pancreatitis, retinopathy, renal impairment, or depression.
• May delay gastric emptying—inform the surgeon before procedures involving anesthesia.
• Advise contraception adjustment if using oral contraceptives—efficacy may be reduced.

✔️ Monitoring & Follow-Up

• Monitor blood glucose levels regularly.
• Assess renal function, vision (for diabetic retinopathy), and thyroid health.
• Perform routine follow-up labs for liver and pancreatic enzymes.

✔️ Storage Instructions

• Store in the refrigerator (2–8°C). Do not freeze.
• Once removed from the fridge, it may be stored at room temp (up to 30°C) for 21 days.
• Do not refreeze after it has reached room temperature.
• Discard used pens and needles safely in a puncture-resistant container.